Search results for "computing methodologies"
showing 10 items of 16 documents
Next-generation sequencing: big data meets high performance computing
2017
The progress of next-generation sequencing has a major impact on medical and genomic research. This high-throughput technology can now produce billions of short DNA or RNA fragments in excess of a few terabytes of data in a single run. This leads to massive datasets used by a wide range of applications including personalized cancer treatment and precision medicine. In addition to the hugely increased throughput, the cost of using high-throughput technologies has been dramatically decreasing. A low sequencing cost of around US$1000 per genome has now rendered large population-scale projects feasible. However, to make effective use of the produced data, the design of big data algorithms and t…
Ibuprofen degradation using a Co-doped carbon matrix derived from peat as a peroxymonosulphate activator
2021
The wider presence of pharmaceuticals and personal care products in nature is a major cause for concern in society. Among pharmaceuticals, the anti-inflammatory drug ibuprofen has commonly been found in aquatic and soil environments. We produced a Co-doped carbon matrix (Co-P 850) through the carbonization of Co2+ saturated peat and used it as a peroxymonosulphate activator to aid ibuprofen degradation. The properties of Co-P 850 were analysed using field emission scanning electron microscopy, energy filtered transmission electron microscopy and X-ray photoelectron spectroscopy. The characterization results showed that Co/Fe oxides were generated and tightly embedded into the carbon matrix …
Sparse kernel methods for high-dimensional survival data
2008
Abstract Sparse kernel methods like support vector machines (SVM) have been applied with great success to classification and (standard) regression settings. Existing support vector classification and regression techniques however are not suitable for partly censored survival data, which are typically analysed using Cox's proportional hazards model. As the partial likelihood of the proportional hazards model only depends on the covariates through inner products, it can be ‘kernelized’. The kernelized proportional hazards model however yields a solution that is dense, i.e. the solution depends on all observations. One of the key features of an SVM is that it yields a sparse solution, dependin…
Efficacy of a blended low-intensity internet-delivered psychological programme in patients with multimorbidity in primary care: study protocol for a …
2019
BackgroundThe World Health Organization (WHO) has included comorbidity between depression and a chronic disease among the 10 leading global health priorities. Although there is a high prevalence of multimorbidity, health care systems are mainly designed for the management of individual diseases. Given the difficulty in delivering face-to-face psychological treatments, alternative models of treatment delivery have been proposed, emphasizing the role of technologies such as the Internet. The aim of this study is to assess the efficacy in Primary Care (PC) of a blended low-intensity psychological intervention applied using information and communication technologies (ICTs) for the treatment of …
Mesh connectivity compression using convection reconstruction
2007
International audience; During a highly productive period running from 1995 to about 2002, the research in lossless compression of 3D meshes mainly consisted in a hard battle for the best bitrates. But for a few years, compression rates seem stabilized around 1.5 bit per vertex for the connectivity coding of usual meshes, and more and more work is dedicated to remeshing, lossy compression, or gigantic mesh compression, where memory and CPU optimizations are the new priority. However, the size of 3D models keeps growing, and many application fields keep requiring lossless compression. In this paper, we present a new contribution for single-rate lossless connectivity compression, which first …
Complete, Exact and Efficient Implementation for Computing the Adjacency Graph of an Arrangement of Quadrics
2007
The original publication is available at www.springerlink.com ; ISBN 978-3-540-75519-7 ; ISSN 0302-9743 (Print) 1611-3349 (Online); International audience; We present a complete, exact and efficient implementation to compute the adjacency graph of an arrangement of quadrics, \ie surfaces of algebraic degree~2. This is a major step towards the computation of the full 3D arrangement. We enhanced an implementation for an exact parameterization of the intersection curves of two quadrics, such that we can compute the exact parameter value for intersection points and from that the adjacency graph of the arrangement. Our implementation is {\em complete} in the sense that it can handle all kinds of…
Low intensity vs. self-guided Internet-delivered psychotherapy for major depression: A multicenter, controlled, randomized study
2013
Abstract Background Major depression will become the second most important cause of disability in 2020. Computerized cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment. No studies on cost-effectiveness of low intensity vs self-guided psychotherapy has been carried out. The aim of this study is to assess the efficacy of low intensity vs self-guided psychotherapy for major depression in the Spanish health system. Methods The study is made up of 3 phases: 1.- Development of a computerized cognitive-behaviour therapy for depression tailored to Spanish health system. 2.- Multicenter controlled, randomized study: A sample (N=450 patients) with mild/mod…
Economic evaluation of a guided and unguided internet-based CBT intervention for major depression: Results from a multicenter, three-armed randomized…
2017
Depression is one of the most common mental disorders and will become one of the leading causes of disability in the world. Internet-based CBT programs for depression have been classified as well established following the American Psychological Association criteria for empirically supported treatments. The aim of this study is to analyze the cost effectiveness at 12-month follow-up of the Internet-based CBT program Smiling is fun with (LITG) and without psychotherapist support (TSG) compared to usual care. The perspective used in our analysis is societal. A sample of 296 depressed patients (mean age of 43.04 years; 76% female; BDI-II mean score = 22.37) from primary care services in four Sp…
Le grand débat national, une aide pour prendre des décisions locales?
2021
The Great National Debate, decided by Emmanuel Macron at the beginning of 2019 to respond to the Yellow Vests social movement, allowed the collection of citizens’ contributions on the ecological transition via an online platform. In this article, we use the corpus constituted by these contributions to identify areas where participants are asking for the development of bicycle paths and railway facilities. For this purpose, we have created a classification model to identify contributions dealing with the theme of transportation and proposed a method for extracting patterns that reflect the contributors’ proposals. We then represented these patterns on maps, using the contributors’ postal cod…
Modélisation géométrique de formes fractales pour la CAO
2020
International audience